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Tirzepatide has been studied across a wide range of body weights (from 40 kg to over 200 kg), with only minor differences in exposure that are not clinically significant enough to warrant dose modifications

In clinical practice, physicians put more emphasis on the presence or absence of similarity between the biochemical profile of the patient and known biochemical profile of the suspected toxicity (e.g., cholestatic damage in amoxycillin-clauvonic acid )

Its given in rotating areas such as the abdomen and thigh

doi: 10.1210/clinem/dgz096 54 QuarellaMWalserDBrndleMFournierJYBilzS

Patients should be particularly vigilant about fluid intake if they experience nausea or reduced appetite, as these semaglutide-related side effects may inadvertently lead to dehydration

This doesn't necessarily mean you should get more magnesium from supplements, though