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Metabolic Synergy The metabolic interactions between these compounds create additional benefits beyond their individual effects

Metformin is not metabolized by hepatic enzymes and is excreted unchanged primarily through the kidneys, while inositol is a water-soluble compound that participates in normal cellular metabolism

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However, it should be noted that other free amino acids, which are present in the blood serum at total 3 mM concentration 42 , can also form tight ternary complexes with Cu(II)-His 45