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GLP-1 also reduces the production of glucagon

If you hit this threshold, its a signal to re-engage with your plan or consult your healthcare provider

Those with a history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, or certain pancreatitis concerns should discuss risks with a provider

or BMI 27 or higher with prediabetes, prior heart attack, prior stroke, or symptomatic peripheral artery disease

In the GLP-1 RA cohort, the risk of DKA remained broadly constant, whilst the risk of DKA within the SGLT2i cohort increased with time and the difference in risk became statistically significant at year 5

Tirzepatide is a dual-agonist, targeting both GLP-1 and GIP receptors, whereas semaglutide is a single-agonist that targets only GLP-1