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Some people have reported serious health events, including hospitalizations, due to taking too much of the drug

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GLP-1Rs are expressed primarily on GABAergic cells in the VTA Next, we showed that a behaviorally relevant dose of exendin-4 that reduced cocaine seeking 8,18 crossed the blood brain barrier, bound putative GLP-1Rs on neurons in the VTA, and induced c-Fos expression in these neurons (Suppl

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One shot, longer effect, just like GLP-1s

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Mounjaro works as a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist

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That 4pm mental fatigue and difficulty concentrating can partly trace here, though sleep debt and screen time are usually the bigger culprits

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Long-term study results are currently limited, but the following must be considered for shaping the clinical algorithm in GLP-1 RA prescribing: proper indication, the characteristics of the prescribed drug, the patient's psychiatric and somatic history, sociodemographic factors, patient expectations, and especially monitoring of response to rapid weight loss (Figure 1)

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