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LY is 2.9-fold less potent than human glucagon at the human GCGR (LY 50% effective concentration [EC 50 ] = 5.79 nM, SEM = 0.28 nM versus human glucagon EC 50 = 1.97 nM, SEM = 0.04 nM) (Figure 1B

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The transmembrane 6 superfamily member 2 (TM6SF2) gene plays a key role in lipid homeostasis by limiting hepatic TG aggregation and influencing VLDL production and lipid droplet composition

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