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Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

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T., rtoft, G., & Oxlund, H

Collagen Loss and Skin Breakdown As we age, collagen production slows and skin becomes thinner, looser, and more fragile