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GHK-Cu has moderate evidence, primarily from topical skin studies

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The result over consistent use is a gradual fading of existing dark spots as the skin's natural cell turnover replaces hyperpigmented surface cells, combined with reduced production of new pigmentation

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6.3 Clinical Symptoms That Should Prompt Assessment Patients on GLP-1 therapy should seek review if experiencing: Persistent fatigue Hair thinning beyond expected telogen shift Neurological symptoms (numbness, tingling) Muscle weakness Persistent vomiting Severe dietary restriction These symptoms are non-specific but warrant nutritional evaluation