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GLP-1 agonists reduce hepatic steatosis primarily through weight loss, improved insulin sensitivity, and decreased hepatic glucose production and lipogenesis
This thrust will put Merck in direct competition with obesity frontrunners Eli Lilly and Novo Nordisk, which are both advancing their respective oral GLP-1 candidates
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Mice were housed in a controlled environment under a 12-h light/dark cycle and with ad libitum access to standard rodent chow and water
It also triggers angiogenesis by upregulating VEGF, flooding follicles with oxygen and nutrients for accelerated keratinocyte proliferation
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