A deficiency in vitamin B12 may be found in persons with a diet limited in animal foods (such as vegans), or those with medical ailments affecting vitamin absorption
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Stabilizing the glutathione cycle can disrupt the feed-forward loop linking oxidative stress, mitochondrial dysfunction, vascular impairment, and cardiometabolic disease
However, POF can progress without clear manifestations, and clinical diagnoses are mostly made during later stages of the disease
This work was supported by a pilot grant from the HIV and Aging Grant CFAR-UAB (R24 AG044325), and a philanthropic donation received from the McNair Medical Institute at The Robert and Janice McNair Foundation.
Hendrickson 2019), and can even be fatal in some cases (Chowdhury et al