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6 DominiciS.PaolicchiA.CortiA.MaellaroE.PompellaA

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Huang CM, Kirchhof MG

A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses

To overcome these limitations, the researchers designed and synthesized novel small molecules with improved metabolic stability, BBB penetrability, and oral activity

Mitochondrial sirtuin 3 (SIRT3) is a major modulator of mitochondrial metabolism and homeostasis, regulating UPR mt , mitochondrial biogenesis, mitophagy, fusion/fission, and antioxidant expression 98