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While B12 shots are often available over the counter, some jurisdictions classify them as prescription medications
I would not prescribe something simply because it becomes accessible
Key pathophysiologic mechanisms include: Mucosal barrier dysfunction: Impaired epithelial tight junctions allow bacterial translocation, triggering innate immune activation T-helper cell dysregulation: Predominantly Th1 and Th17 pathways drive chronic inflammation via TNF-, IL-12, IL-23 the basis for biologic therapy targets Transmural inflammation: Unlike UC (mucosal only), CD involves all layers: mucosa submucosa muscularis propria serosa Granuloma formation: Non-caseating granulomas are pathognomonic but present in only ~3050% of biopsies Fibrosis and stricture: Chronic inflammation activates myofibroblasts collagen deposition luminal narrowing obstructive symptoms Fistula formation: Transmural ulcers penetrate serosa form sinus tracts connect to adjacent bowel, bladder, vagina, or skin 7
The QUBO model predicted BMS-986094 as the second-best candidate and Tanimoto predicted several forms of cobamamide, also known as vitamin B12
For a 220-pound (100 kg) starting weight, thats roughly 33 pounds
Every treatment is ordered by a licensed clinician and administered by a Registered Nurse under physician supervision, consistent with the requirements of HB 3749
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