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CO 2 can suppress histamine release in mast cells by increasing intracellular Calcium levels (ref)

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93,96,97 In addition, although emerging markers such as serum immunoreactive trypsin and chymotrypsin show theoretical potential, their clinical utility remains to be validated through further studies

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Because of the rapid growth of tumors, tumor region consist of anoxic and aerobic parts depending on whether they are located in the vicinity of blood vessels