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A chelating agent that will occupy more of the coordination positions of a metal ion will generally (but not always) give a complex of greater stability than otherwise

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doi: 10.4088/JCP.8157su1c.04

The concept of non conjugated bilirubin as a powerful antioxidant could be the answer, from a teleological point of view, to mammals necessities for producing bilirubin and not stopping the catabolic chain from heme to biliverdin (BV) like amphibian, reptiles and birds do (10)

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A positive effect of carotenoid (lutein, zeaxanthin) supplementation on cognitive functions among elderly individuals has been reported in several studies