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Emerging evidence suggests the new class of weight loss medications like semaglutide and tirzepatide (best known by brand name medications like Ozempic and Zepbound) might help people with substance use disorder by reducing the desire to use alcohol and other drugs
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The pilot program will only be operational for ten medications and aims to start on January 1, 2026
The first phase 3 retatrutide trial, TRIUMPH-4, top-line data announced today Retatrutide, a triple GLP-1,GIP, glucagon agonist studied in patients with obesity and osteoarthritis 28.7% weight loss at 68 weeks Reduced key cardiometabolic risk markers non-HDL cholesterol, triglycerides, and hsCRP Highest dose lowered systolic BP by 14 mmHg Reduced WOMAC pain scores by up to an average of 4.5 points (75.8%) and significantly improved measures of physical function GI side effects most common adverse event We now await 7 additional phase 3 trials in other obesity related comorbidities Retatrutide May Redefine Multi-Receptor Therapeutics Triple agonism (GLP-1 + GIP + glucagon) isnt just about adding more receptors this distinct mechanism can boost energy expenditure, not just suppress appetite
therefore, WD-fed MC4R-KO mice are advantageous as a rodent MASH model owing to their ability to be established quickly
