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This leads to a greater reliance on glycolysis, which serves to not only generate ATP but also metabolic intermediates to feed the pentose phosphate pathway

Several other next-generation medications are also in development, each approaching weight management from different angles: Retatrutide is a new medication from Eli Lilly in trials that targets three hormones that control appetite and metabolism

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However, besides Sj and Sp (discussed above), other non- Saccharomyces strains might be exploited for this purpose

4f, quantification: Fig

Importantly, discontinuation of semaglutide after 20 weeks of treatment led to regain of body weight, whereas maintaining treatment led to continued body-weight loss over an additional 48 weeks of treatment, underlining that life-long treatment is necessary to maintain treatment effect [37]