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Harwaldt P, Rahlfs S, Becker K

Additional phylogenetic analyses were performed using the Maximum Likelihood method based on the Jones-Taylor-Thornton (JTT) matrix-based model (Jones et al., 1992), which gave overall similar results (Figure S1B)

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On the other hand, in pathological conditions such as early diabetic nephropathy, inappropriate upregulation of SQOR leads to excessive consumption of signaling H 2 S, resulting in insufficient H 2 S signaling and exacerbated tissue damage ( 2 S, but to maintain H 2 S concentrations within an optimal steady-state windowand when this balance is lost in either direction, opposite pathological consequences ensue