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In a post hoc analysis of the SURPASS-1 trial involving patients with T2DM, the percentage increase in adiponectin levels from baseline ranged from 16% to 23% with tirzepatide compared to a decrease of 0.2% with placebo at week 40 (190)

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References: Effects of Semaglutide on Chronic Kidney Disease in Type 2 Diabetes, Perkovic V

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[95% CI 0.571.11]