In the repeated administration study, we observed a gradually increasing elimination of carnitine via urine over a 7day treatment period, suggesting a decrease in OCTN2 transport capacity in the presence of elevated carnitine levels
Dormancy Period: Possibly days to years
Alba M, Fintini D, Sagazio A, et al
These combination therapies could provide patients with more options and potentially reduce the need for more invasive procedures
Even 2x per week makes significant difference
The SELECT trial authors acknowledged as much themselves, noting in their supplementary appendix that South Asians face greater cardiometabolic risk at lower BMIs, yet didnt look at people with a BMI below 27 precisely where risk concentrates for Asian populations