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Additionally, metabolic profiling has revealed that suppression of GLS1 induces a compensatory anaplerotic mechanism via pyruvate carboxylase (PC), which allows the release of a glutamine-independent supply of TCA intermediates by catalyzing the transformation of pyruvate to oxaloacetate 153

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It was proven that PLCAR prevents the peripheral neuropathy connected with diabetes or toxic chemotherapy, improving nervous conductivity and blood flow in peripheral nerves [81]

PMID: 18856211