how does glp 1 affect the brain Mechanisms of glucagon-like-peptide in beyond metabolic effects Effects of central GLP‐1 on

Other research highlights: 30% of GLP-1 users tested positive for SIBO or IMO even after accounting for diabetes (5) GLP-1 medicines caused microbiome changes and altered metabolism in mice (6) GLP-1 medicines tested in humans only had noticeable microbiome changes by 48 weeks (7) Despite not necessarily having slower gut motility, one study found that 88.9% of obese patients had SIBO (8) A meta analysis of people with IBS symptoms, found that up to 78% of people had SIBO, many of whom were undiagnosed (9) Overall, Sun and colleagues (1) could not prove a mechanistic link between GLP-1 medications and SIBO, however they did find that SIBO was twice as likely in GLP-1 users

Picking Your Most Optimal Injection Site GLP-1 medications are administered through subcutaneous injection

doi: 10.1038/nrn3961 202 CandeiasESebastioICardosoSCarvalhoCSantosMSOliveiraCRet al

A PowerLab unit (PowerLab 16/35, AD Instruments) was used to record ECG and blood pressure at a sampling rate of 4 kHz

3, 6 They calm brain inflammation

Diabetes Metab Res Rev (2010) 26(4):28796