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Impairment in the regulation of the IGF axis plays a significant role in both the proliferation of cells and the inhibition of apoptosis

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However, it is important to note that the analysis of the present review focused primarily on the folate-dependent pathway, which constitutes a limitation because it excludes other nutrients involved in epigenetic regulation, such as choline, serine and vitamins B12 and B6, all of which participate in SAM availability and overall methylation capacity (175,176)

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