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Key findings from early trials include: Sustained weight loss over nearly one year of treatment Improvements in blood sugar control, with many participants achieving normal HbA1c levels Reduced liver fat content, beneficial for metabolic health Generally well-tolerated side effect profile These results represent some of the most substantial weight loss outcomes observed in clinical trials for obesity medications

Mas recientemente, los inhibidores del cotransportador sodio-glucosa tipo 2 han demostrado ofrecer proteccin cardiovascular y renal, pero el riesgo residual sigue siendo alto y su eficacia antihiperglucemiante es limitada en ERC moderada-severa

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Epicardial adipose tissue assessed by computed tomography and echocardiography are associated with adverse cardiovascular outcomes: a systematic review and meta-analysis

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Marso SP, et al