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Pancreatitis and Gallbladder Issues : There have been concerns about pancreatitis and gallbladder-related issues

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By binding to actin monomers, it creates a reserve of cellular building blocks that are rapidly deployed to help cells move into a damaged area to begin reconstruction

(2025) T2DM: 46.5% discontinued by 1 year 64.1% discontinued by 2 years Without T2DM: 64.8% discontinued by 1 year 84.4% discontinued by 2 years Key Factors Linked to Discontinuation: Higher rates among patients without T2DM Age 65 years More likely to discontinue Higher weight loss during treatment Associated with lower discontinuation rates Moderate to severe GI side effects Higher likelihood of stopping treatment Higher income (T2DM only) Lower discontinuation rates Reinitiation of GLP-1: Source: Rodriguez PJ, Zhang V, Gratzl S, et al

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