Approximately one-third of patients lost more than 20% of body weight at 68 weeks of the STEP 2 trial, so it really is a breakthrough drug. Semaglutide at a Glance Level of Concern Should ophthalmologists be concerned about an uptick of DR progression in a new cohort of patients
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PMID: 40353578
Clinical trials didnt see double-digit percentage weight drops until participants reached 1.7 mg and stayed there for at least 12 weeks (Rubino et al., JAMA 2021)
Real-world results vary based on starting weight, adherence, and lifestyle factors, but most patients at Dr
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