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Abbreviations FAO: Fatty Acid Oxidation acyl-CoA: acyl-Coenzyme A BCAA: Branched-Chain Amino Acid BCAC: Branched-Chain Acylcarnitine LCAC: Long-Chain Acylcarnitine OXPHOS: Oxidative Phosphorylation BCFA: Branched-Chain Fatty Acid VLCFA: Very Long-Chain Fatty Acid C16-Carnitine: palmitoylcarnitine CPT1A: Carnitine Palmitoyltransferase 1 A TML: 6-N-trimethyllysine TMLD: 6-N-trimethyllysine dioxygenase HTML: 3-hydroxy-6-N-trimethyllysine TMABA: 4-N-trimethylaminobutyraldehyde HTMLA: 3-hydroxy-6-N-trimethyllysine aldolase TMABA DH: 4-N-trimethylaminobutyraldehyde Dehydrogenase BB: -Butyrobetaine BBD: -Butyrobetaine Dioxygenase OCTN: Organic Cation Transporter Novel CrAT: Carnitine Acetyltransferase CrOT: Carnitine Octanoyltransferase TMA: Trimethylamine TMAO: Trimethylamine-N-oxide TMAVA: Trimethyl-5-Aminovaleric Acid PDC: Pyruvate Dehydrogenase IRI: Ischemia-Reperfusion injury AKT: Protein Kinase B PI3K: Phosphatidylinositol-3-Kinase AMPK: AMP-Activated Protein Kinase JNK: c-Jun N-terminal Kinase mTOR: mechanistic Target Of Rapamycin MAPK: Mitogen-Activated Protein Kinase NF-B: Nuclear Factor B Nrf2: the Nuclear factor E2-related factor 2 TNF-: Tumor Necrosis Factor CAT: Catalase COX-2: Cyclooxygenase-2 ERK: Extracellular signal-Regulated Kinase ROS: Oxygen Species MDA: Malondialdehyde SOD: Superoxide Dismutase MyD88: Myeloid Differentiation factor 88 ER: Endoplasmic Reticulum PGC-1: Peroxidase proliferator-activated receptor coactivator-1 PPAR: Peroxisome Proliferator-Activated Receptor GST: Glutathione-S-Transferase GSH: Reduced Glutathione GSH-Px: Glutathione peroxidase GSSG: Oxidized Glutathione TBARS: Thiobarbituric Acid Reactive Substances NLRP3: NOD-Like Receptor Thermal Protein Domain Associated Protein 3 COX2: Cyclooxygenase-2 Cyt c: Cytochrome c HO-1: Heme Oxygenase-1 FOXO: Forkhead box O IGF-1: Insulin like Growth Factor-1 BDNF: Brain-Derived Neurotrophic Factor NGF: Nerve Growth Factor NQO1: NAD(P)H Quinone Oxidoreductase 1 References Baker SA, Rutter J
The good news is, you have more control over your glutathione levels than you might think
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It's delicate
GPX4-IN-3 (26a) exhibits IC50 values of 0.78 M, 6.9 M, 0.15 M and 4.73 M in 4T1, MCF-7, HT1080 and HT1080 (with Fer-1) cells, respectively[1].GPX4-IN-3 (26a) exhibits outstanding GPX4 inhibitory activity with a percent inhibition up to 71.7% at 1.0 M compared to 45.9% of RSL-3[1].GPX4-IN-3 (26a) could significantly induce lipid peroxide (LPO) increase and effectively induce ferroptosis with satisfactory selectivity[1].GPX4-IN-3 (26a) is more likely to induce ferroptosis through the accumulation of intracellular peroxides via inhibiting GPX4 activity[1].GPX4-IN-3 (26a) significantly increased the level of ROS in 4T1 cells, which could also be reversed by Ferrostatin-1 (fer-1)[1]
