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Some doctors take a similar approach with a drug called 5-fluorouracil (5-FU), which subdues collagen-making fibroblast cells to get a scar to proliferate less, he adds
Interrogation of the ATM data revealed specific proinflammatory transcripts, including the interferon response genes Gbp3 and Mx2 , CXCL chemokine family members ( Cxcl19 , Cxcl11 , Cxcl10 ), and C-C motif chemokine ligand 5 ( Ccl5 ), that were commonly upregulated in PAR2 mutants when compared with PAR2-WT mice (Supplemental Figure 7B)
NF-kB is a master transcription factor that controls the expression of hundreds of genes involved in inflammation, immune activation, and cell survival