Extracorporeal treatment, including HDF, should be considered early in the management of VPA intoxication
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To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig
Graphical abstract Access this article Similar content being viewed by others Data availability Data that support the findings of this study are available by the Lombardy Region, but restrictions apply to the availability of these data and codes, which were used under license for the current study, and so they are not publicly available
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