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In aged Rhesus monkeys, Epitalon treatment stimulated melatonin production and restored youthful secretion patterns, while also normalizing cortisol rhythms in a time-of-daydependent manner [59]

(1) CY 2026 Direct Supervision in RHCs/FQHCs We have considered information from interested parties, particularly in response to the CY 2024 PFS proposed rule where we solicited comment on potential patient safety or quality concerns when direct supervision occurs virtually in RHCs and FQHCs

It has not been approved by the FDA or any other major global regulatory body for human therapeutic use

Timing: Any steady weekly schedule works

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