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Indeed, iGPX4 may be a promising target for NAFLD therapy as activated iGPX4 interacts with the canonical cGPX4 by transforming cGPX4 from enzymatically active monomers to enzymatically inactive oligomers in response to lipid stress, which exacerbates ferroptosis (Tong et al., 2022)
GSH is under tight homeostatic control both intracellularly and extracellularly
10.1016/j.ebiom.2023.104494 9 ChenM.WeiS.WuX.XiangZ.LiX.HeH.et al (2024)
Lateef OM, Akintubosun MO
Despite their popularity, the annual cost of GLP-1 drugs is staggering at upwards of $11,000 at list prices
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