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The delayed gastric emptying induced by GLP-1 medications means food remains in the stomach for longer periods

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Importantly, the GI AEs associated with semaglutide are frequent but should not overshadow its treatment benefits, especially considering the low incidence of thyroid cancer

Additional mechanisms include modulation of gut microbiota composition, inhibition of mitochondrial complex I, and effects on lipid metabolism

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"A deletion mutation in the ApoC-II gene (ApoC-II Nijmegen) of a patient with a deficiency of apolipoprotein C-II"