SURPASS-2 results (40 weeks, type 2 diabetes): Tirzepatide 5 mg: -7.6 kg weight loss, -2.01% HbA1c reduction Tirzepatide 10 mg: -9.3 kg weight loss, -2.24% HbA1c reduction Tirzepatide 15 mg: -11.2 kg weight loss, -2.30% HbA1c reduction Semaglutide 1 mg: -5.7 kg weight loss, -1.86% HbA1c reduction SURMOUNT-5 results (72 weeks, obesity): Tirzepatide demonstrated statistically superior weight loss compared to semaglutide 2.4 mg
I dont really have any other options
Articles like how long reconstituted peptides last in the fridge provide more specific data on semaglutide stability timelines
That it also inhibited the glucagon secretion that we talked about
The only difference is concentration
STEP 1 Trial - New England Journal of Medicine : The landmark clinical trial demonstrating 14.9% average weight loss with semaglutide 2.4mg over 68 weeks, establishing the efficacy and safety profile for weight management