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This is a foundational part of how the medication works for weight loss, but it creates a traffic jam for other oral substances

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Neurons are unable to dilute cellular waste products through cell division and are therefore vulnerable to breakdowns in autophagy (Nixon, 2020), which leads to the buildup and aggregation of misfolded proteins and the accumulation of damaged mitochondria (Yang et al., 2024)

European countries are also often more restrictive with prescriptions, initially limiting them to specialist settings or structured weight-management programs