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(90) demonstrated the role of the CCL2/CCR2 signaling axis in IECs and showed the importance of immune crosstalk between IECs and underlying immune cell populations in whole-body glucose homeostasis ( Figure 2 )

10.1016/j.nantod.2024.102323 38 Chiorcea-PaquimA.-M

Specifically, circulating LPS binds to TLR4 on immune cell surfaces, activating the downstream NF-B signaling pathway and promoting the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)