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This tri-agonist mechanism distinguishes it from currently approved agents such as semaglutide or tirzepatide

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Additionally, disruption of the balance between mitochondrial fission and fusion, along with impaired fatty acid metabolism, is closely linked to intracellular calcium overload in various cell types [3335]

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It can be used alongside caloric restriction without exacerbating hunger, combined with exercise programs without compromising fueling needs, or integrated with behavioral nutrition approaches that rely on intact hunger and satiety signaling for long-term habit formation