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JR, KK and MB analysed the experiments with input from BM and TPD

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DOI: 10.1002/biof.5520190309

GPX4 inhibition with RSL3 induces ferroptosis, lipid peroxidation and reactive oxygen species (ROS) in thyroid cancer cells in vitro We targeted the ferroptosis pathway in PTC cells in vitro using a pharmacologic inhibitor of GPX4, RSL3

The variant was also linked to a higher risk of gastrointestinal side effects, which can themselves suppress appetite and contribute to weight loss