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Variants in GLP1R (the GLP-1 receptor itself), GIPR (the GIP receptor that tirzepatide also activates), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide

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UK REACH, Safety Data Sheets and COSHH Where a substance is lawfully supplied as a laboratory chemical, medicines law may not be the only relevant framework