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Prior research has shown that estrogen amplifies GH release by counteracting somatostatin inhibition and enhancing GHRH signaling, while antiestrogens may reduce IGF-1 receptor expression, thereby modifying the biological effects of IGF-1 [2]

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A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network

Eur J Endocrinol (2012) 166:38390

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