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Rana A, Ahmed M, Rub A, Akhter Y (2015) A tug-of-war between the host and the pathogen generates strategic hotspots for the development of novel therapeutic interventions against infectious diseases

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A striking human illustration of how the system is organized comes from ALS deficiency, in which loss of the ternary complex profoundly lowers circulating IGF-1 yet produces only a mild growth phenotype a discrepancy attributed to the continued action of locally produced, autocrine/paracrine IGF-1 in the tissues themselves

Hypoglycemia (Low Blood Sugar) IGF-1 mimics the action of insulin by promoting glucose uptake into muscle cells

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