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454 Dexamethasone is a glucocorticoid drug that is often used to reduce symptoms caused by inflammation and an overreaction of the immune system

Nevertheless, administration of tissue plasminogen activator (tPA), the only approved thrombolytic agent, is constrained by its limited therapeutic window of three hours and by complications derived from hemorrhagic risks, reperfusion injury, and its own intrinsic toxicity (3)

Despite these facts, there are indications that melatonin may cause decreased neonatal biometric parameters in pregnancies of sheep exposed to chronic hypoxia due to high altitude, so further studies are needed in this specific population [82]