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The BCSFB barrier is composed of an ependymal epithelium that produces the CSF, characterized by apical tight junctions located at the choroid plexuses

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

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The ongoing degradation of NRF2 ensures that only the basal expression levels of NRF2 target genes are maintained, supporting essential housekeeping functions

However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

Toxicology and applied pharmacology 257 , 338348, doi: 10.1016/j.taap.2011.09.017 (2011)