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10.1016/S0006-8993(01)03267-X Brain Res

Blocking TGF- signaling genetically (SMAD3 / ) and pharmacologically (anti-TGF- antibody, 1D11) in mice lead to protective effects: decreased body weight gain and fat mass, improved insulin sensitivity, ameliorated hepatic steatosis

Detailed codes for outcomes are shown in Supplemental Table 2

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Data from mouse experiments suggested that nitric oxide (NO) pathways might contribute to increased cavernosal pressure when melanocortin receptors are activated, though these findings remain tentative and require further validation