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Both of these primitive chaperones, CRAM-1 and MOAG/SERF1, impair survival and could act as non-competitive inhibitors of the proteasome in an age-dependent manner relevant to AD (Ayyadevara et al., The high levels of oxidized proteins detected in the brains of AD patients are an indirect indication of proteasome impairment, since this proteolytic complex degrades the majority of oxidatively modified proteins (Grune et al., 2004)

Monitoring depression trends on Twitter during the COVID-19 pandemic: observational study

An era of uncertainty

Hiramatsu G, Hisamura M, Murase M, Kukihara Y, Nakamura M

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Regional differences in bloodbrain barrier permeability in cognitively normal elderly subjects: a dynamic contrast-enhanced MRI-based study