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As such, an exaggerated response is seen in the face of the adrenergic surge associated with physiologic stressors such as sepsis or trauma, yielding thyroid storm

Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months

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That represents roughly a two-fold weakening of the appetite feedback circuit compared to dieting alone

The goal is to build a clearer picture of who might benefit most and how these medications fit into the broader landscape of mental health treatment

Continuous use without cycling can lead to receptor desensitization, diminishing returns, and unknown long-term effects