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In a 2017 endotoxemia model, TB-500 at 100 mcg/kg intraperitoneal injection reduced serum TNF-, IL-1, and IL-6 by 40 to 55% within four hours of LPS challenge

56 demonstrated that the administration of exenatide (2 wk) to adult rodents induced an elevation in DCX and mammalian achaete scute homolog-1 (Mash-1) gene transcripts, both markers of neurogenesis in the hippocampus

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In some research contexts, periodic breaks may actually enhance outcomes by allowing receptor upregulation during rest periods, improving responsiveness when dosing resumes