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Metformin acts in the gut and induces gutliver crosstalk

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J Biol Chem 293(23):90179029 Yang KC, Breitbart A, De Lange WJ, Hofsteen P, Futakuchi-Tsuchida A, Xu J, Schopf C, Razumova MV, Jiao A, Boucek R, Pabon L, Reinecke H, Kim DH, Ralphe JC, Regnier M, Murry CE (2018) Novel adult-onset systolic cardiomyopathy due to MYH7 E848G mutation in patient-derived induced pluripotent stem cells

Variability in study protocols, glutamine dosages, and patient cohorts may contribute to the divergent findings, emphasizing the need for standardized approaches, and larger, well-controlled trials to elucidate the true impact of glutamine supplementation on mucositis and other treatment-related toxicities