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GLP-1 agonists like semaglutide and tirzepatide can be used alongside biologics for conditions such as rheumatoid arthritis or psoriatic arthritis

GIP-related neuromodulatory effects have also been proposed, although respiratory-specific evidence remains limited (39, 41)

We propose a metabolic risk reproductive timeline framework to delineate optimal GLP-1RA use, incorporating specific therapeutic windows and discontinuation protocols

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Orforglipron influences multiple intracellular signaling pathways downstream of GLP-1 receptor activation, including the cAMP-PKA pathway and phosphorylation of key transcription factors, which are essential in regulating appetite, satiety, and various metabolic processes such as glucose homeostasis and lipid metabolism