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In serum, first-episode, antipsychotic-nave patients show reductions in TRP, KYN, KYNA, anthranilic acid, and modestly lower 3-HK and QA, indicating early KP dysregulation, and long-term antipsychotic treatment partially normalizes these metabolites [238]

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A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins

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