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Accordingly, altered HSP expression has been implicated in the pathogenesis of multiple metabolic disorders, positioning HSPs as both biomarkers of disease severity and promising, albeit complex, therapeutic targets (Fig

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The potential impact of EDCs on thyroid hormone regulation in children is of particular concern as thyroid hormones play a crucial role in the growth and central nervous system development, and control the overall physiological homeostasis (66, 67)

Therefore, whether these immunomodulatory effects translate to a neuroprotective phenotype in the context of MS remains a critical open question that can only be addressed in disease-relevant preclinical models, such as Experimental Autoimmune Encephalomyelitis (EAE)

how these states perpetuate fibrogenesis without inducing overt cell death requires further investigation

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