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That is the sensation that you get with GLP1 therapies and it is experienced by about 10-20% of people but the vast majority of these symptoms settle after around about 8-12 weeks in most people and if somebody were in a situation where they felt nauseated there is no reason that they need to escalate from 0.25mg up to 0.5mg until that nausea has settled

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It's also not listed as a potential side effect in the prescribing information for Ozempic or Wegovy

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It's important to note that semaglutide may not be suitable for those with a history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, pancreatitis, or severe gastrointestinal disorders