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NAFLD-associated chronic low-grade inflammation responds to L-carnitine supplementation through reduced hepatic pro-inflammatory cytokines (e.g., IL-6), increased anti-inflammatory cytokine IL-10, and downregulation of key inflammatory pathway components (TLR4, NF-B, JNK) ( NF-B represents a master regulator of inflammatory responses in NAFLD progression

The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency